Related Experiment Video
Updated: Apr 27, 2026

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
Published on: October 27, 2023
Formation and development of maxillary first molars with delayed eruption
Natsuki Sano1, Takashi Kameda2, Yukari Terashima2
1Department of Orthodontics, The Nippon Dental University School of Life Dentistry at Niigata, 951-8580, Hamaura-chou 1-8, Chuuou-ku, Niigata, Japan. natsuki@ngt.ndu.ac.jp.
Delayed eruption of the maxillary first molar (M1) is rare but occurs. Despite a delayed start, M1s develop and erupt faster than usual, aiding orthodontic treatment planning.
Area of Science:
- Dentistry
- Orthodontics
- Pediatric Dentistry
Background:
- Congenitally missing or delayed eruption of the maxillary first molar (M1) is uncommon.
- Recent observations suggest an increase in suspected M1 delayed eruption or absence.
- M1s are crucial for proper occlusion.
Purpose of the Study:
- To analyze the formation and eruption patterns of delayed erupted maxillary first molars (M1).
- To compare the development and eruption timelines of M1 with normal maxillary first molars (U6).
- To provide insights for orthodontic treatment planning in cases of M1 anomalies.
Main Methods:
- A retrospective analysis of patients born between 1974-1994 with M1 anomalies.
- Evaluation of panoramic X-rays from 73 patients (131 M1s) using Moorrees's tooth formation stages.
- Fitting development/growth curves (logistic and U6) to M1 formation and eruption pathways.
Main Results:
- The frequency of M1 anomalies was 1.55% in the studied cohort.
- M1 development and eruption curves showed a faster inclination compared to U6 after an initial delay.
- The eruption pathway of M1 followed a sigmoid S-shape curve.
Conclusions:
- Despite a delayed onset, the developmental and migration speed of M1 is accelerated.
- Understanding these accelerated dynamics is vital for effective orthodontic treatment planning for M1 anomalies.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Development of the Oral Microbiota
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
Bone Formation by Endochondral Ossification
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

