Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

791
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
791
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

699
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
699
Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.7K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes on risky drinking after the COVID-19 outbreak in Brazil: results from three consecutive web surveys.

Trends in psychiatry and psychotherapy·2024
Same author

Premorbid intelligence quotient and school failure as risk markers for bipolar disorder and major depressive disorder.

Journal of psychiatric research·2023
Same author

Cannabidiol as an Adjunctive Treatment for Acute Bipolar Depression: A Pilot Study: Le cannabidiol comme traitement d'appoint de la dépression bipolaire aiguë : une étude pilote.

Canadian journal of psychiatry. Revue canadienne de psychiatrie·2023
Same author

U-SMILE: a brief version of the Short Multidimensional Inventory on Lifestyle Evaluation.

Trends in psychiatry and psychotherapy·2023
Same author

Lifestyle in bipolar disorder: A cross-sectional study.

Spanish journal of psychiatry and mental health·2023
Same author

Predicting functional impairment in euthymic patients with mood disorder: A 5-year follow-up.

Psychiatry research·2023

Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
05:19

Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

Published on: July 7, 2023

3.8K

[Bipolar disorder: staging and neuroprogression].

Aline André Rodrigues, Adriana R Rosa, Maurício Kunz

    Psychiatria Polska
    |July 15, 2014
    PubMed
    Summary

    Illness progression in bipolar disorder, marked by mood episodes and impairment, suggests staging models are valuable. Early intervention and precise diagnosis improve patient outcomes and prognosis.

    Area of Science:

    • Psychiatry
    • Neuroscience
    • Clinical Psychology

    Context:

    • Bipolar disorder is characterized by illness progression, leading to increased mood episodes, hospitalizations, and functional decline.
    • Staging models, proven effective in other conditions, are increasingly recognized for their potential in managing bipolar disorder.

    Purpose:

    • To review the clinical and biological evidence supporting the concept of illness progression in bipolar disorder.
    • To explore the utility of staging models for refining diagnosis, guiding treatment, and informing prognosis.

    Summary:

    • Illness progression in bipolar disorder correlates with adverse outcomes, including treatment resistance and cognitive impairment.
    • Staging models offer a framework to tailor interventions based on illness stage, potentially improving treatment response.

    More Related Videos

    Developing a Rat Model for Bipolar Disorder
    04:42

    Developing a Rat Model for Bipolar Disorder

    Published on: May 2, 2025

    1.7K
    The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
    11:35

    The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

    Published on: June 30, 2014

    58.9K

    Related Experiment Videos

    Last Updated: Apr 27, 2026

    Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
    05:19

    Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment

    Published on: July 7, 2023

    3.8K
    Developing a Rat Model for Bipolar Disorder
    04:42

    Developing a Rat Model for Bipolar Disorder

    Published on: May 2, 2025

    1.7K
    The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
    11:35

    The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

    Published on: June 30, 2014

    58.9K
  • Assessing cognition, functioning, and comorbidities is crucial for effective staging and personalized treatment planning.

    • Impact:

    • Staging bipolar disorder can lead to more precise diagnoses and personalized treatment strategies.
    • Implementing staging models may enhance patient and family understanding of prognosis and expected illness trajectory.
    • Early intervention informed by staging could mitigate the long-term severity and functional impact of bipolar disorder.