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Matrix metalloproteinase-9 (mmp-9) expression in different subtypes of ameloblastoma
Rachmitha Anne1, Ening Krisnuhoni2, Chusnul Chotimah1
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Indonesia, Jl. Salemba Raya No. 4, Jakarta Pusat, 10430 Indonesia.
Background:
Ameloblastoma is a common benign odontogenic tumor of the jaw with a local invasive and highly destructive behavior and can develop in any age, with peak prevalence in 3rd-4th decade. Ameloblastoma can be divided into six histological types: follicular, plexiform, acanthomatous, desmoplastic, granular, and basal cell. Matrix metalloproteinase-9 (MMP-9) (92-kD gelatinase/type IV collagenases = gelatinase B) is involved in bone resorption by degradation of extracellular matrix and osteoclasts recruitment. Recent studies have found that MMP-9 is expressed by ameloblastoma and has a role in ameloblastoma local invasiveness.
Objective:
To analyze MMP-9 expression between different histological types of ameloblastoma.
Material And Method:
Forty samples of ameloblastoma were collected through consecutive sampling and the MMP-9 expression was detected using immunohistochemistry.
Result:
All samples showed positive MMP-9 expression with moderate to strong intensity. 82.4 % plexiform type and 83.3 % mixed type have strong immunoexpression, significantly different with follicular type with only 36.4 % (P < 0.05).
Conclusion:
Ameloblastoma plexiform and mixed type have higher MMP-9 expression than ameloblastoma follicular type. Different MMP-9 expression may contribute in different ameloblastoma biological behavior.
