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Published on: January 24, 2025
NIR-triggered drug release from switchable rotaxane-functionalized silica-covered Au nanorods
Menghuan Li1, Hong Yan, Cathleen Teh
1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore. zhaoyanli@ntu.edu.sg.
Abstract:
An NIR-triggered drug delivery system was developed by capping photo-switchable azobenzene-based rotaxane onto Au nanorod-mesoporous silica core-shell hybrids. Drug release from the nanocarrier in zebrafish embryo models could be controlled remotely under NIR irradiation, showing significant drug spreading to the adjacent tissues.
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