Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

ABC Transporters: Exporter

ABC Transporters: Exporter

ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...

ABC Transporters: Importer

ABC Transporters: Importer

ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...

The Significance of Membrane Transport

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...

Membrane Transporters

Membrane Transporters

Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PROTOCOL: Interventions Targeting Misinformation, Disinformation and Malinformation for Reducing and Countering Violent Extremism: A Systematic Review.

Campbell systematic reviews·2026

Same author

Remote cognitive training for older adults using tablets: A pilot trial.

Digital health·2026

Same author

Combined Modeling Approaches for Assessing Sodium-Iodide Symporter Inhibition.

Journal of chemical information and modeling·2026

Same author

Leveraging Consensus Docking Approaches for Human Mitochondrial Complexes I and III.

Chemical research in toxicology·2025

Same author

Exploring the Cell Biological and Functional Effects of the First Disease Associated KCC1 Genetic Variant.

Journal of cellular physiology·2025

Same author

Data-driven assessment of bioisosteric replacements and their influence on off-target activity profiles.

RSC medicinal chemistry·2025

Search research articles

Related Experiment Video

Updated: Apr 27, 2026

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR

Published on: November 29, 2014

Computational models for predicting the interaction with ABC transporters.

Marta Pinto, Daniela Digles, Gerhard F Ecker

Drug Discovery Today. Technologies

|July 17, 2014

Summary

This summary is machine-generated.

ATP-binding cassette (ABC) transporters significantly impact drug behavior. This review covers computational ligand-based models used to predict how these transporters interact with various drug molecules.

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

A Triple Culture Cell System Modeling the Human Blood-Brain Barrier

A Triple Culture Cell System Modeling the Human Blood-Brain Barrier

Published on: November 30, 2021

Related Experiment Videos

Last Updated: Apr 27, 2026

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR

Real Time Measurements of Membrane Protein:Receptor Interactions Using Surface Plasmon Resonance SPR

Published on: November 29, 2014

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

A Triple Culture Cell System Modeling the Human Blood-Brain Barrier

A Triple Culture Cell System Modeling the Human Blood-Brain Barrier

Published on: November 30, 2021

Area of Science:

Pharmacology
Computational Chemistry
Biochemistry

Background:

ATP-binding cassette (ABC) transporters are crucial in drug pharmacokinetics and pharmacodynamics.
Their role necessitates computational methods for predicting drug-transporter interactions.

Purpose of the Study:

To provide a comprehensive overview of current ligand-based computational models for ABC transporters.
To summarize models derived from ligand transport and inhibitory activities.

Main Methods:

Literature review of published ligand-based models for ABC transporters.
Analysis of models based on ligand transport and inhibitory data.

Main Results:

Several ligand-based computational models have been developed for ABC transporters.
These models utilize transport and inhibitory activities of various ligands.

Conclusions:

Ligand-based models represent a significant advancement in understanding ABC transporter-ligand interactions.
These models are valuable tools for predicting drug behavior influenced by ABC transporters.