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Related Experiment Video

Updated: Apr 26, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
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[Renal denervation in ADPKD: an exceptional case].

Eleonora Riccio, Antonella Di Nuzzi, Antonio Mancini

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |July 18, 2014
    PubMed
    Summary

    Renal denervation successfully lowered blood pressure (BP) in a patient with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and treatment-resistant hypertension. This case demonstrates the potential of renal denervation for managing refractory hypertension in ADPKD patients.

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    Area of Science:

    • Nephrology
    • Cardiology
    • Interventional Radiology

    Background:

    • Autosomal Dominant Polycystic Kidney Disease (ADPKD) is frequently associated with severe arterial hypertension.
    • Sympathetic overactivity is a key factor in hypertension development and worsening in ADPKD.
    • Renal denervation is an established treatment for resistant hypertension in chronic kidney disease (CKD) but lacks data in ADPKD.

    Observation:

    • A case report of a woman with stage 4 CKD due to ADPKD and uncontrolled, treatment-resistant hypertension.
    • Previous pharmacological and surgical interventions, including uninephrectomy, were ineffective.
    • Renal denervation using radiofrequency ablation of the renal artery was performed due to therapeutic limitations.

    Findings:

    • The patient experienced a significant reduction in antihypertensive medication requirements.
    • Blood pressure (BP) showed a remarkable and sustained decrease 12 months post-procedure.
    • Renal denervation proved effective in managing refractory hypertension in this ADPKD patient.

    Implications:

    • This case suggests renal denervation as a viable therapeutic option for hypertension in ADPKD patients.
    • Further research is warranted to explore the efficacy and safety of renal denervation in a larger ADPKD cohort.
    • Renal denervation may offer a new avenue for controlling resistant hypertension in this specific patient population.