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Standardization and quantification in PET/CT imaging: tracers beyond FDG.

Lidija Antunovic¹, Marcello Rodari¹, Pietro Rossi¹

¹Nuclear Medicine Department, Humanitas Clinical and Research Institute, Via A. Manzoni 56, Rozzano, Milan 20089, Italy.

|July 18, 2014

Summary

Standardization of Fluorodeoxyglucose (FDG) PET-CT is emerging in clinical trials. Protocols for non-FDG radiopharmaceuticals are not yet standard, but FDG experience can guide future standardization efforts.

Keywords:

Harmonization Imaging Positron emission tomography Quantification Radiopharmaceuticals Standardization

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Area of Science:

Nuclear Medicine
Radiopharmaceutical Science
Medical Imaging

Background:

Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography (FDG PET-CT) standardization is advancing, particularly in clinical trial settings.
The use of non-FDG radiopharmaceuticals in PET/CT is currently not standardized for clinical trials or routine practice.

Purpose of the Study:

To highlight the current variability in protocols and indications for non-FDG radiopharmaceuticals in PET/CT.
To propose a pathway towards standardization based on existing FDG PET-CT protocols.

Main Methods:

Review of existing protocols and indications for various radiopharmaceuticals used in PET/CT.
Comparative analysis of FDG PET-CT standardization efforts versus non-FDG radiopharmaceuticals.
Illustrative examples of different protocols and their clinical applications.

Main Results:

Significant variability exists in the standardization of non-FDG radiopharmaceuticals for PET/CT imaging.
FDG PET-CT serves as a model for developing standardized protocols for other radiotracers.
The future likely involves widespread adoption of standardized PET/CT protocols across various radiopharmaceuticals.

Conclusions:

Standardization of PET/CT imaging is crucial for consistent clinical trial results and reliable clinical use.
Leveraging the experience gained from FDG PET-CT standardization can facilitate the adoption of standards for other radiopharmaceuticals.
Implementing standardized acquisition and interpretation protocols for diverse radiopharmaceuticals will enhance the utility of PET/CT imaging globally.