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Updated: Apr 26, 2026

Detection of Copy Number Alterations Using Single Cell Sequencing
Published on: February 17, 2017
Computational methods for DNA copy-number analysis of tumors
Jude Kendall1, Alexander Krasnitz
1Cold Spring Harbor Laboratory, 1 Bungtown Road, 11724, Cold Spring Harbor, NY, USA.
Abstract:
Study of DNA copy-number variation is a key part of cancer genomics. With the help of a comprehensive multistep computational procedure described here, copy-number profiles of tumor tissues or individual tumor cells may be generated and interpreted, starting with data acquired by next-generation sequencing. Several of the methods presented are specifically designed to handle cancer-related copy-number profiles. These include accounting for variation of ploidy and distilling somatic copy number alterations from the inherited background.
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