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Acute effect of primary percutaneous coronary intervention on left ventricular dyssynchrony in ST-segment elevation

Sinan İnci1, Şule Karakelleoğlu, M Hakan Taş

  • 1Department of Cardiology, Faculty of Medicine, Atatürk University; Erzurum-Turkey. doktorsinaninci@gmail.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|July 19, 2014
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly reduces left ventricular (LV) dyssynchrony in patients with ST-elevation myocardial infarction (MI) during the acute phase. This improvement was observed using Tissue Synchronization Imaging, demonstrating the effectiveness of PCI in managing LV function post-MI.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Interventional Cardiology

Background:

  • ST-segment elevation myocardial infarction (STEMI) can lead to significant left ventricular (LV) dysfunction and dyssynchrony.
  • Early assessment of LV dyssynchrony is crucial for guiding treatment and predicting outcomes in STEMI patients.
  • Tissue Synchronization Imaging (TSI) offers a method to quantify LV dyssynchrony.

Purpose of the Study:

  • To prospectively evaluate the impact of percutaneous coronary intervention (PCI) on left ventricular (LV) dyssynchrony in the acute phase of ST-segment elevation myocardial infarction (STEMI).
  • To utilize Tissue Synchronization Imaging (TSI) to assess changes in LV dyssynchrony before and after PCI in STEMI patients.

Main Methods:

  • Forty-four STEMI patients admitted within 12 hours of symptom onset were enrolled.
  • Echocardiography measurements using TSI were performed before and 3-6 days after PCI.
  • LV dyssynchrony was quantified by measuring the time to peak systolic velocity in alternate ventricular segments.

Main Results:

  • Significant reductions in LV dyssynchrony were observed in both anterior and inferior STEMI groups post-PCI compared to pre-PCI measurements.
  • Specific segments, including basal anterior, mid-anterior, basal septal, mid-septal, and basal/mid-inferior, showed significant improvements.
  • Intraventricular dyssynchrony indices between anterior and inferior segments were notably lower after PCI.

Conclusions:

  • Percutaneous coronary intervention (PCI) effectively decreases left ventricular (LV) dyssynchrony in the acute period for ST-elevation myocardial infarction (STEMI) patients.
  • TSI is a valuable tool for assessing the functional impact of PCI on LV mechanics in STEMI.
Abstract

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