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Legg-Calvé-Perthes disease and the risk of ADHD, depression, and mortality

Yasmin D Hailer1, Olle Nilsson

  • 1Department of Orthopedics , Uppsala University Hospital, Uppsala , Sweden.

Acta Orthopaedica
|July 19, 2014
PubMed

Insights

Individuals with Legg-Calvé-Perthes disease (LCPD) have a significantly higher risk of attention deficit hyperactivity disorder (ADHD), depression, and mortality. These findings suggest a potential link between hyperactivity and LCPD development and increased risks for associated conditions.

Area of Science:

  • Orthopedics
  • Pediatric Orthopedics
  • Neurodevelopmental Disorders

Background:

  • Legg-Calvé-Perthes disease (LCPD) is a hip condition affecting children.
  • A hyperactive behavior pattern, such as attention deficit hyperactivity disorder (ADHD), has been suggested to be associated with LCPD.

Purpose of the Study:

  • To investigate the risk of ADHD, depression, and mortality in individuals diagnosed with LCPD.
  • To explore potential links between LCPD and neurobehavioral conditions and overall mortality.

Main Methods:

  • A cohort study identified 4,057 individuals with LCPD in Sweden (1964-2011).
  • A control group of 40,570 individuals without LCPD was randomly selected and matched by age, sex, and region.
  • Cox proportional hazard regression was used to analyze relative risks.

Main Results:

  • Individuals with LCPD showed a 1.5-fold increased hazard ratio (HR) for ADHD compared to controls, with higher risks in females.
  • A modestly higher HR for depression (1.3) and a slightly higher HR for mortality (1.2) were observed in the LCPD group.
  • Increased mortality risks were linked to suicide and cardiovascular diseases.

Conclusions:

  • LCPD is associated with a significantly elevated risk of ADHD, depression, and mortality.
  • Hyperactivity may contribute to the mechanical stress leading to LCPD.
  • The increased depression risk may stem from LCPD's burden or neurobehavioral factors, while higher mortality warrants further investigation.
Abstract

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