Association between three eNOS polymorphisms and cancer risk: a meta-analysis.
Xun Wu1, Zhi-Feng Wang, Yin Xu
1Department of Anatomy, School of Basic Medicine Science, Southern Medical University, Guangzhou, ChinaE-mail : zxsuwu@126.com.
Asian Pacific Journal of Cancer Prevention : APJCP
|July 22, 2014
Summary
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene are linked to cancer risk. The T-786C variant increases overall cancer risk, while G894T and 4a/b variants are associated with specific cancers in females and prostate cancer, respectively.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene are investigated for their potential role in cancer development.
- Previous studies on the association between eNOS gene polymorphisms and cancer risk have yielded conflicting results, necessitating a comprehensive analysis.
Purpose of the Study:
- To systematically review and meta-analyze existing studies to clarify the association between eNOS gene polymorphisms and cancer risk.
- To provide a more precise estimation of the risk conferred by specific eNOS polymorphisms.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, EMBASE, EBSCO, Google Scholar, CNKI) up to April 2014.
- Thirty-one eligible studies comprising cancer patients and controls were included in the meta-analysis.
- Statistical analysis was performed using multiple genetic models to assess the association between eNOS polymorphisms and cancer risk.
Main Results:
- The T-786C polymorphism showed a significant association with increased overall cancer risk across various genetic models.
- The G894T polymorphism was linked to a higher risk of cancer in females and specifically for breast cancer.
- The 4a/b polymorphism was associated with an increased susceptibility to prostate cancer.
Conclusions:
- The eNOS T-786C polymorphism is associated with elevated cancer risk.
- The eNOS G894T polymorphism contributes to cancer susceptibility in females, including breast cancer.
- The eNOS 4a/b polymorphism may play a role in the risk of developing prostate cancer.
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