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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Mitral Stenosis I: Introduction01:22

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Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
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Mitral Valve Prolapse II: Assessment and Management01:22

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Regurgitation I: Introduction01:20

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Mitral Valve Prolapse I: Introduction01:27

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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Related Experiment Video

Updated: Apr 26, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
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Percutaneous mitral valve repair preserves right ventricular function.

Annelieke C M J van Riel1, Kirsten Boerlage-van Dijk2, Rianne H A C M de Bruin-Bon2

  • 1Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands; ICIN - Netherlands Heart Institute, Utrecht, The Netherlands.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|July 22, 2014
PubMed
Summary

Percutaneous mitral valve repair with MitraClip does not harm right ventricular function. Successful repair improves RV afterload and functional class, while residual issues may worsen outcomes.

Keywords:
MitraClipMitral regurgitationMitral stenosisPercutaneous mitral valve repairRight ventricular functionTransthoracic echocardiography

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Echocardiography

Background:

  • Chronic mitral regurgitation (MR) can impair right ventricular (RV) function.
  • Surgical interventions may further compromise RV function.
  • The impact of percutaneous mitral valve (MV) repair on RV function is not well understood.

Purpose of the Study:

  • To evaluate the effect of percutaneous MV repair using the MitraClip system on RV systolic function and afterload.
  • To assess changes in RV parameters following MitraClip implantation over a 6-month period.

Main Methods:

  • Transthoracic echocardiography was performed at baseline, 1, and 6 months post-MitraClip implantation.
  • RV systolic function was assessed using five echocardiographic parameters.
  • RV afterload was evaluated by systolic pulmonary arterial pressure and mean MV pressure gradient.

Main Results:

  • No significant changes in RV parameters were observed 6 months after MitraClip implantation.
  • Mitral regurgitation decreased significantly (P < .01) post-procedure.
  • Patients with residual MR and mitral stenosis showed higher systolic pulmonary arterial pressure and lower NYHA functional class.

Conclusions:

  • Percutaneous MV repair does not negatively impact RV function, unlike surgical approaches.
  • Successful MitraClip repair improves RV afterload and New York Heart Association functional class.
  • Residual MR and mitral stenosis after repair can adversely affect RV afterload and functional status.