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Updated: Apr 26, 2026
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Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes
Published on: September 27, 2018
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[Pathogenicity of Mycobacterium kansasii]
S Vesenbeckh1, S Wagner2, H Mauch2
1Klinik für Pneumologie, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin.
Pneumologie (Stuttgart, Germany)
|July 22, 2014
Summary
Mycobacterium kansasii infections are less pathogenic than previously reported, with 68% of cases showing clinical disease. This study supports current diagnostic criteria for non-tuberculous mycobacteria (NTM) infections.
Area of Science:
- Pulmonary Medicine
- Microbiology
- Infectious Diseases
Context:
- Non-tuberculous mycobacteria (NTM) cause pulmonary infections.
- A prior study reported 100% disease rates for Mycobacterium kansasii infections.
- Re-evaluation of M. kansasii pathogenicity in a large lung disease center was warranted.
Purpose:
- To re-evaluate the pathogenicity of Mycobacterium kansasii in patients with lung diseases.
- To compare disease rates with previous multi-center study findings.
- To assess the utility of diagnostic criteria for M. kansasii infections.
Summary:
- This study evaluated 37 patients with M. kansasii isolates, finding clinical disease in 68% and asymptomatic infection in 32%.
- Underlying conditions included COPD, bronchiectasis, TB scars, and alcohol abuse.
- Genotype I was identified in 30 strains, with 73% considered pathogenic.
Impact:
- Findings challenge the previously reported 100% pathogenicity of M. kansasii.
- Supports the use of clinical and semiquantitative microbiological criteria for diagnosing M. kansasii infections.
- Contributes to understanding the spectrum of M. kansasii lung disease and infection.
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