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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Updated: Apr 26, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
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Environmental triggers for IBD.

Aoibhlinn O'Toole1, Joshua Korzenik

  • 1BWH Crohn's and Colitis Center, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

Current Gastroenterology Reports
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Summary
This summary is machine-generated.

Environmental factors and the gut microbiome play key roles in inflammatory bowel disease (IBD) development and flares. Understanding these interactions is crucial for developing new treatments to restore gut health and prevent IBD.

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Area of Science:

  • Gastroenterology and Immunology
  • Microbiome Research
  • Environmental Health

Background:

  • Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), arises from complex interactions between genetic predisposition and environmental triggers.
  • The precise mechanisms by which environmental factors initiate IBD and disease flares are not fully understood.
  • Genetic factors alone are insufficient; environmental influences are critical in disease manifestation.

Purpose of the Study:

  • To elucidate the role of environmental influences in the pathophysiology of IBD.
  • To explore the contribution of environmental factors to gut dysbiosis in IBD.
  • To highlight the potential of microbiome restoration for IBD treatment and prevention.

Main Methods:

  • Review and synthesis of current literature on IBD pathogenesis.
  • Analysis of the interplay between genetic susceptibility, environmental exposures, and the intestinal microbiome.
  • Discussion of the impact of dysbiosis on IBD development and progression.

Main Results:

  • Environmental factors are significant contributors to IBD initiation and flares, acting in concert with genetic predispositions.
  • The intestinal microbiome is a pivotal element in IBD development, with dysbiosis playing a critical role.
  • Identifying specific environmental triggers is essential for understanding disease mechanisms.

Conclusions:

  • A comprehensive understanding of environmental influences on the gut microbiome is vital for managing IBD.
  • Targeting environmental factors and restoring microbial balance offers therapeutic potential for IBD flares and prevention.
  • Further research into the environmental-microbiome-host axis is needed to combat IBD effectively.