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The heat shock protein-CD91 pathway mediates tumor immunosurveillance
Yu Jerry Zhou1, Robert Julian Binder1
1Department of Immunology; University of Pittsburgh; Pittsburgh, PA USA.
Oncoimmunology
|July 23, 2014
Abstract:
Tumor immunosurveillance can be readily observed in mice and humans. Here, we examine how T-cell responses are primed during tumorigenesis, a condition in which immunostimulatory antigens are extraordinarily scarce. We recently demonstrated that the HSP-CD91 pathway is indispensable for antigen cross-presentation, and thus immunosurveillance, in cancer.
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