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Updated: Apr 26, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Natural killer T cell strategies to combat Epstein-Barr virus infection
John J Priatel1, Brian K Chung2, Kevin Tsai1
1Child and Family Research Institute; Immunity in Health and Disease; University of British Columbia; Vancouver, BC Canada ; Department of Pathology and Laboratory Medicine; University of British Columbia; Vancouver, BC Canada.
Abstract:
Epstein-Barr virus (EBV) infection results in rapid loss of CD1d expression from the surface of infected B cells, thus enabling the virus to evade immune recognition by natural killer T (NKT) cells. Using pharmacologic means to boost CD1d expression, potent NKT cell effector functions can be elicited toward EBV-infected B cells, suggesting the promise of novel strategies to target EBV-associated diseases such as some B-cell malignancies.
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