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Effect of resveratrol on exercise capacity: a randomized placebo-controlled crossover pilot study
Nha Voduc1, Charles la Porte, Caroline Tessier
1a Department of Medicine, Division of Respirology, University of Ottawa at The Ottawa Hospital, General Campus, 501 Smyth Road, Box 211, Ottawa, ON K1H 8L6, Canada.
Resveratrol supplementation did not improve exercise capacity in healthy adults. However, it led to more gastrointestinal issues and minor changes in blood markers, though none were clinically significant.
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Supplement Research
Background:
- Resveratrol is a polyphenol found in grapes and red wine, known for potential health benefits.
- Its effects on exercise performance and metabolic markers in healthy sedentary individuals are not well-established.
Purpose of the Study:
- To evaluate the impact of resveratrol supplementation on exercise capacity.
- To assess the tolerability and safety of resveratrol in healthy adults.
Main Methods:
- A randomized, placebo-controlled crossover study was conducted.
- Thirteen healthy, sedentary adults participated, with two 4-week treatment periods (resveratrol vs. placebo) separated by a 2-week washout period.
Main Results:
- No significant changes were observed in exercise duration or peak oxygen uptake.
- Gastrointestinal side effects were significantly more frequent with resveratrol (77% vs. 15%).
- Minor, though statistically significant, increases in liver enzymes, total cholesterol, and triglycerides were noted, remaining within normal ranges. Fasting glucose showed a small reduction.
Conclusions:
- Resveratrol supplementation does not enhance exercise capacity in healthy sedentary adults.
- Resveratrol is associated with increased gastrointestinal adverse effects and minor, non-clinically significant alterations in metabolic and liver markers.
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