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[Value of probiotic in reducing frequency of infectious complications in premature infants]

L A Lo Skiavo, N V Gonchar, A N Suvorov

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |July 24, 2014
    PubMed

    Insights

    Administering the probiotic E. faecium L3 to premature infants significantly reduced infectious complications. This intervention supported the gut

    Area of Science:

    • Neonatal care
    • Microbiology
    • Pediatric gastroenterology

    Context:

    • Premature infants with very low body weight require intensive care.
    • Standard care includes resuscitation, respiratory support, nutrition, and antimicrobial therapy.
    • Assessing novel interventions to improve outcomes in this vulnerable population is crucial.

    Purpose:

    • To evaluate the effectiveness of the probiotic E. faecium L3 in reducing infectious complications in premature infants.
    • To assess the impact of probiotic supplementation on nutritional support and intestinal microflora.
    • To compare outcomes between infants receiving standard care plus probiotics and those receiving standard care alone.

    Summary:

    • A study observed 55 premature infants, with 29 receiving standard care plus oral probiotic E. faecium L3 and 26 receiving standard care only.
    • The probiotic group showed a significant decrease in infectious complications (20.7%) compared to the control group (53.9%).
    • Probiotic use helped maintain the immunomodulatory function of the intestinal microflora and limited the growth of nosocomial bacteria.

    Impact:

    • The findings suggest E. faecium L3 can be an effective adjunct therapy for premature infants.
    • Reduced infectious complications can lead to shorter hospital stays and improved infant health outcomes.
    • This research highlights the role of probiotics in modulating the gut microbiome for enhanced neonatal immunity.

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