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[NERVOUS REGULATION OF BILIARY TRACT MOTILITY].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
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[SEROTONERGIC REGULATION OF IMMUNITY. PART I].

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Updated: Apr 26, 2026

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
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[Prolactin and serotonin].

A E Lychkovq, A M Puzikov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |July 25, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Prolactin (PRL) plays a role in breast and prostate cancer development. Studies show PRLR polymorphism and potential therapeutic applications of PRL inhibitors in breast cancer treatment.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Prolactin (PRL) is a hormone with diverse physiological roles.
    • PRL and its receptor (PRLR) are implicated in various cellular processes.
    • Aberrant PRL signaling is linked to cancer development.

    Purpose of the Study:

    • To provide an overview of prolactin research.
    • To examine the molecular and genetic aspects of PRL and PRLR.
    • To explore the role of PRL in cancer and its therapeutic potential.

    Main Methods:

    • Literature review of studies on prolactin.
    • Analysis of molecular and genetic characteristics of PRL and PRLR.
    • Investigation of PRLR polymorphism in breast tumor patients.

    Main Results:

    • PRLR polymorphism is associated with breast tumors.
    • Synthesized PRL analogues demonstrated inhibition of peripheral PRL effects.
    • The vegetative nervous system influences PRL secretion.
    • PRL is identified as a risk factor for breast and prostate cancers.

    Conclusions:

    • PRL signaling mechanisms are characterized.
    • PRL's potential clinical use in breast cancer therapy is discussed.
    • Understanding PRL pathways is crucial for cancer prevention and treatment.