Luteal deficiency caused by human ovarian follicular fluid peptide in post-partum marmosets, Callithrix jacchus

A peptide purified from human ovarian follicular fluid (hOFFP) was administered during the follicular phase of post-partum marmosets. Four of the five animals treated with hOFFP, ovulated as evidenced by the presence of ovarian stigmata at the time of laparotomy. However, only 2 of these animals became pregnant, one had a normal delivery while the other aborted. A shortening of the luteal phase was observed in the other three animals and all animals conceived in subsequent cycles. The results indicated that treatment with the ovarian follicular fluid peptide resulted in impairment of fertility as a result of luteal insufficiency.