Related Experiment Video
Updated: Apr 26, 2026

Author Spotlight: Enhanced Urodynamic Method for Precise Urine Measurement in Awake Mice with Neurogenic Bladder
Published on: June 7, 2024
Neurogenic lower urinary tract dysfunction: how, when, and with which patients do we use urodynamics?
Teresa L Danforth1, David A Ginsberg2
1Department of Urology, SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, 100 High Street, Suite B280, Buffalo, NY 14203, USA.
Neurogenic lower urinary tract dysfunction (NLUTD) management focuses on monitoring and preventing upper tract disease. High detrusor leak point pressures indicate risk, necessitating tailored urodynamic study timing based on patient condition.
Area of Science:
- Urology
- Neuroscience
- Pediatrics
Background:
- Neurogenic lower urinary tract dysfunction (NLUTD) impacts numerous patients, demanding vigilant monitoring.
- Identifying patients at risk for upper tract disease is crucial for timely intervention.
Purpose of the Study:
- To highlight the importance of monitoring patients with NLUTD.
- To discuss the specific challenges and considerations for urodynamic studies in NLUTD patients.
- To emphasize the goals of managing NLUTD, including maintaining low bladder pressures, reducing infection risk, and preserving continence.
Main Methods:
- Review of initial studies on risk stratification for upper tract disease in NLUTD.
- Analysis of urodynamic study timing in different patient populations (acute injury, spinal dysraphism).
Main Results:
- High detrusor leak point pressures were identified as predictive of upper tract disease.
- Delayed urodynamics are recommended post-spinal shock in acute injury cases.
- Early urodynamics are advised for children with spinal dysraphism to assess risk.
Conclusions:
- Effective management of NLUTD requires careful monitoring and risk assessment.
- Urodynamic study protocols must be adapted to the specific clinical context of NLUTD patients.
- Achieving low bladder pressures, preventing infections, and maintaining continence are paramount in NLUTD care.
Related Concept Videos
Urodynamic Studies: Uroflowmetry
Anatomy of the Genitourinary System II: Bladder and Urethra
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
Urinary Bladder
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Microbiota of the Urogenital Tract
Physiology of the Genitourinary System III: Urine Concentration and Dilution

