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Targeted multimodal imaging modalities.

Seung Yong Lee1, Seong Ik Jeon1, Seulhee Jung1

  • 1Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, Gwanak-ro 1, Gwanak, Seoul 151-744, Republic of Korea.

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Targeted multimodal imaging probes offer precise disease diagnosis by combining multiple imaging techniques. These advanced probes enhance accuracy and enable imaging-guided therapy for improved patient outcomes.

Keywords:
Active targetingImaging probesMolecular imagingMultimodalityTargeting moieties

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Area of Science:

  • Molecular imaging and biomedical engineering.
  • Development of advanced diagnostic and therapeutic tools.

Background:

  • Molecular imaging enables non-invasive visualization of biological processes at the molecular level.
  • Multimodal imaging integrates various modalities for enhanced diagnostic precision, offering high spatial resolution, soft tissue contrast, and molecular sensitivity.
  • Challenges remain in developing single probes for all modalities, particularly for low-sensitivity components requiring high-dose contrast agents.

Purpose of the Study:

  • To review and discuss targeted multimodal imaging probes categorized by modality.
  • To highlight advancements in imaging instruments, probes, assays, and quantification techniques.
  • To explore the potential of targeted multimodal imaging in theranostics and imaging-guided therapy.

Main Methods:

  • Review of existing literature on targeted multimodal imaging probes.
  • Categorization of probes based on individual imaging modalities.
  • Discussion of probe design, targeting moieties, and theranostic applications.

Main Results:

  • Targeting moieties enhance specific binding and accumulation at disease sites, improving diagnostic accuracy.
  • Multimodal probes offer complementary advantages over single modalities.
  • Targeted multimodal agents can carry therapeutic payloads for theranostic applications.

Conclusions:

  • Targeted multimodal imaging probes represent a significant advancement in disease diagnosis and treatment.
  • The integration of therapeutic agents enables visualization of theranostic effects and disease progression.
  • Further development will expand the application of targeted multimodal imaging in preclinical and clinical settings, particularly for imaging-guided therapy.