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Clinical outcomes of compensated and decompensated cirrhosis: A long term study

Dimitrios N Samonakis1, Mairi Koulentaki1, Constantina Coucoutsi1

  • 1Dimitrios N Samonakis, Mairi Koulentaki, Constantina Coucoutsi, Aikaterini Augoustaki, Chryssavgi Baritaki, Emmanuel Digenakis, Nikolaos Papiamonis, Maria Fragaki, Erminia Matrella, Elias A Kouroumalis, Department of Gastroenterology and Hepatology, University Hospital of Heraklion, Heraklion 71110, Crete, Greece.

World Journal of Hepatology
|July 29, 2014
PubMed

Insights

Cirrhosis prognosis varies by cause and severity. Hepatitis C virus patients had longer survival, while alcohol contributed to higher decompensation risk. Hepatitis B virus patients faced increased hepatocellular carcinoma risk.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Cirrhosis is a significant health concern with varying prognostic patterns.
  • Understanding these patterns is crucial for patient management and survival prediction.

Purpose of the Study:

  • To investigate the characteristics and prognostic patterns of cirrhosis in a Greek patient cohort.
  • To identify predictors of survival and decompensation in cirrhotic patients.

Main Methods:

  • Analysis of a large cohort of 522 cirrhotic patients (compensated and decompensated) from 1991-2008.
  • Prospective data collection on cirrhosis aetiology, decompensation, hepatocellular carcinoma (HCC) occurrence, and survival.
  • Statistical analysis of differences in outcomes based on cirrhosis aetiology and presentation.

Main Results:

  • Hepatitis C virus (HCV) was the most common aetiology (41%), followed by alcohol (31%).
  • Median survival was significantly longer in compensated (115 mo) versus decompensated (55 mo) cirrhotics.
  • HCV patients survived longer than HBV patients; alcoholics had the highest decompensation risk; HBV patients had the highest HCC risk.

Conclusions:

  • Cirrhosis aetiology and decompensation status at presentation are key predictors of patient survival.
  • Alcohol-related cirrhosis carries the highest risk of decompensation.
  • Hepatitis B virus (HBV) cirrhosis is associated with the highest risk of hepatocellular carcinoma (HCC).
Abstract

Keywords:
AscitesBleedingDecompensationHepatocellular carcinomaSurvival

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