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Matrix metalloproteinases and peripheral arterial disease

I Giagtzidis1, C Karkos, G Pitoulias

  • 1Fifth Surgical Department, Hippokrateio General Hospital, Thessaloniki, Greece - kimisnet@gmail.com.

International Angiology : a Journal of the International Union of Angiology
|July 30, 2014
PubMed

Insights

Atherosclerosis is an inflammatory disease where matrix metalloproteinases (MMPs) are key biomarkers. This review explores the link between MMPs and peripheral arterial disease (PAD) progression and manifestations.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Inflammation Research

Background:

  • Atherosclerosis is increasingly recognized as a chronic inflammatory vascular disease.
  • Peripheral arterial disease (PAD) represents a significant clinical manifestation of atherosclerotic vascular disease.
  • Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of vascular conditions.

Purpose of the Study:

  • To review the current scientific literature on the association between matrix metalloproteinases (MMPs) and peripheral arterial disease (PAD).
  • To elucidate the role of MMPs in the initiation, progression, and clinical presentation of PAD.

Main Methods:

  • Comprehensive literature search of relevant scientific databases.
  • Synthesis and analysis of existing research on MMPs and PAD.
  • Review of studies investigating MMPs as biomarkers in PAD.

Main Results:

  • Matrix metalloproteinases (MMPs) are significantly associated with peripheral arterial disease (PAD).
  • Specific MMPs play critical roles in the development and advancement of PAD.
  • MMPs are identified as important circulating biomarkers for PAD.

Conclusions:

  • Matrix metalloproteinases (MMPs) are integral to the inflammatory processes underlying peripheral arterial disease (PAD).
  • Understanding the MMP-PAD axis offers potential for novel diagnostic and therapeutic strategies.
  • Further research into MMPs could enhance the management of atherosclerotic vascular disease.

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