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Updated: Apr 26, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

25.4K

Contractile reserve induced with dobutamine echocardiography predicts outcome in patients with left ventricular

Robert R Moss, Simona L Bar, Mann Chandavimol

    The Journal of Heart Valve Disease
    |August 1, 2014
    PubMed

    Insights

    Contractile reserve (CR) in patients with mitral regurgitation (MR) and left ventricular dysfunction (LVD) predicts better outcomes. Dobutamine stress echocardiography (DSE) identified CR, significantly reducing the risk of death or heart transplantation.

    Area of Science:

    • Cardiology
    • Echocardiography
    • Heart Failure Management

    Background:

    • Management of mitral regurgitation (MR) with left ventricular dysfunction (LVD) remains controversial.
    • Assessing contractile reserve (CR) may aid in risk stratification for these patients.

    Purpose of the Study:

    • To determine if CR, assessed by dobutamine stress echocardiography (DSE), is associated with improved outcomes in patients with MR and LVD.
    • Investigate the prognostic value of CR in this patient population.

    Main Methods:

    • 125 patients with LVEF ≤ 35% and significant MR underwent DSE.
    • CR was defined as a > 10% increase in LVEF during dobutamine infusion.
    • Primary outcomes were death and heart transplantation.

    Main Results:

    • 43% of patients demonstrated CR.
    • CR was associated with a significantly lower rate of death or heart transplantation within five years (12.7% vs. 34.3%, p < 0.01).
    • CR independently predicted reduced mortality and need for transplantation, even after adjusting for clinical factors.

    Conclusions:

    • In patients with advanced LVD and severe MR, CR detected by DSE is a significant predictor of improved survival.
    • DSE-derived CR can inform clinical decision-making for patients with complex heart conditions.
    Abstract

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