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Src regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation

Rachel Vistein1, Manojkumar A Puthenveedu

  • 1Department of Biological Sciences, The Center for the Neural Basis of Cognition, Carnegie Mellon University, MI202, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA.

Traffic (Copenhagen, Denmark)
|August 1, 2014
PubMed
Summary

Signaling receptors like the beta-2 adrenergic receptor (B2AR) use specialized pathways for recycling. This process is controlled by Src kinases targeting cortactin, regulating receptor delivery to the cell surface.

Keywords:
GPCRSrcactin cytoskeletoncortactincrosstalkendosomeheterologous regulationregulated recyclingsequence-dependent recyclingtraffickingtubulesvesicle scission

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