Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

30.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
30.1K
Epigenetic Regulation01:37

Epigenetic Regulation

3.4K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.4K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
Epigenetic Regulation01:46

Epigenetic Regulation

24.0K
24.0K
Forced Transdifferentiation01:28

Forced Transdifferentiation

1.5K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
1.5K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recovery of high-quality sperm after cryopreservation in the common marmoset (Callithrix jacchus)†.

Biology of reproduction·2026
Same author

Best practices for cryopreserving sperm in Nonhuman Primates: a systematic review and meta-analysis.

Scientific reports·2025
Same author

Impacts of social isolation stress in safety learning and the structure of defensive behavior during a spatial-based learning task involving thermal threat.

Frontiers in behavioral neuroscience·2024
Same author

Benchmarks defining high-quality sperm in the common marmoset (Callithrix jacchus).

Andrology·2024
Same author

An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis.

eLife·2024
Same author

Endocrine disruptor-induced epimutagenesis <i>in vitro</i> : Insight into molecular mechanisms.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Apr 26, 2026

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.4K

Distinctions between transgenerational and non-transgenerational epimutations.

John R McCarrey1

  • 1Department of Biology, University of Texas at San Antonio, San Antonio, USA.

Molecular and Cellular Endocrinology
|August 1, 2014
PubMed
Summary
This summary is machine-generated.

Environmental factors can cause epimutations in mammals. Some epimutations are corrected, while others are passed down through generations, but the reasons for this difference remain unclear.

Keywords:
DNA methylationEnvironmental disruptorsEpigeneticsEpimutationsTransgenerational epigenetic inheritance

More Related Videos

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

911
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.6K

Related Experiment Videos

Last Updated: Apr 26, 2026

Author Spotlight: RNAi Inheritance and ChIP in C. elegans
10:28

Author Spotlight: RNAi Inheritance and ChIP in C. elegans

Published on: May 5, 2023

5.4K
Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
05:55

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

Published on: June 17, 2025

911
In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
10:44

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing

Published on: May 5, 2023

2.6K

Area of Science:

  • Epigenetics and Environmental Health
  • Mammalian Epigenetics
  • Transgenerational Inheritance

Background:

  • Environmental exposures can induce epigenetic changes (epimutations) in mammals.
  • Epimutations can be corrected by germline reprogramming or persist across generations.
  • Mechanisms distinguishing transgenerational from non-transgenerational epimutations are not well understood.

Purpose of the Study:

  • To review potential molecular and developmental factors influencing epimutation inheritance.
  • To explore mechanisms behind the transgenerational transmission of epimutations.
  • To identify distinctions between heritable and non-heritable epimutations.

Main Methods:

  • Literature review of epigenetic reprogramming in mammals.
  • Analysis of molecular mechanisms underlying epimutation stability.
  • Examination of developmental processes affecting epigenetic inheritance.

Main Results:

  • Identified potential molecular markers differentiating transgenerational epimutations.
  • Highlighted developmental windows critical for epigenetic inheritance.
  • Discussed the role of epigenetic reprogramming efficiency in epimutation persistence.

Conclusions:

  • Epimutation inheritance depends on specific molecular and developmental factors.
  • Further research is needed to fully elucidate mechanisms of transgenerational epigenetic inheritance.
  • Understanding these distinctions is crucial for assessing environmental health risks.