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Updated: Apr 26, 2026

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
Published on: August 11, 2011
A novel preclinical murine model of immune-mediated metastatic dormancy
Irene Romero1, Federico Garrido2, Angel M Garcia-Lora1
1Servicio de Analisis Clinicos e Inmunologia; UGC Laboratorio Clínico; Instituto de Investigación Biosanitaria ibs.GRANADA; Hospital Universitario Virgen de las Nieves; Granada, Spain.
Abstract:
The mechanisms underlying cancer dormancy are poorly understood. We have developed a preclinical murine model in which immunosurveillance restrains spontaneous metastases in permanent dormancy. The model faithfully recapitulates human metastatic dormancy and may be useful to decipher the immune mechanisms constraining disease progression, thereby facilitating the development of novel immunotherapeutic approaches to control metastatic disease.
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