Related Experiment Video

Updated: Apr 26, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Prospects for personalized targeted therapies for cutaneous squamous cell carcinoma

John C Mavropoulos, Bishr Aldabagh, Sarah T Arron1

  • 1Department of Dermatology, University of California in San Francisco (UCSF) Dermatologic Surgery and Laser Center, UCSF School of Medicine CA USA.

Seminars in Cutaneous Medicine and Surgery
|August 3, 2014
PubMed

Insights

Targeted therapies for cutaneous squamous cell carcinoma (cSCC) are limited due to genetic complexity. New strategies like EGFR inhibition, immunotherapy, and vaccines show promise for personalized cSCC treatment.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Genetics

Background:

  • Cutaneous squamous cell carcinoma (cSCC) presents limited targeted therapy options.
  • The genetic heterogeneity of cSCC hinders effective molecular characterization and treatment development.

Purpose of the Study:

  • To explore emerging targeted therapies for cutaneous squamous cell carcinoma.
  • To discuss novel treatment strategies including immunotherapy and vaccine-based approaches for cSCC.

Main Methods:

  • Review of current research on targeted therapies for cSCC.
  • Investigation into the potential of epidermal growth factor receptor (EGFR) inhibition.
  • Analysis of immune checkpoint blockade and vaccine-based therapies for cSCC.

Main Results:

  • Epidermal growth factor receptor (EGFR) inhibition shows potential as a targeted therapy for cSCC.
  • Immune checkpoint blockade and vaccine-based methods offer novel, personalized treatment avenues.
  • Combination therapies may provide a multi-pronged approach to cSCC treatment.

Conclusions:

  • Personalized treatment strategies are crucial for advancing cSCC therapy.
  • Targeted therapies, including EGFR inhibitors and immunotherapies, are under active investigation.
  • A combination of emerging treatments holds promise for improving outcomes in cSCC.

More Related Videos

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

9.1K
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

6.0K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

1.5K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K