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Updated: Apr 26, 2026
09:54
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
Published on: December 3, 2019
9.2K
[Don't miss the primary HIV-infection]
Dominique L Braun1, Johannes Nemeth1, Huldrych F Günthard1
1Klinik für Infektionskrankheiten und Spitalhygiene, Universitätsspital Zürich, Universität Zürich.
Therapeutische Umschau. Revue Therapeutique
|August 6, 2014
Summary
Primary HIV infection (PHI) is a critical transmission period, often presenting with vague symptoms. Early HIV testing with 4th generation Combo tests and prompt antiretroviral therapy are crucial for management.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Context:
- Primary HIV infection (PHI) is the initial 6-month period post-HIV acquisition.
- PHI is responsible for a significant proportion of ongoing HIV transmissions.
- Clinical manifestations of PHI are diverse, ranging from acute retroviral syndrome to asymptomatic or atypical presentations.
Purpose:
- To highlight the diagnostic challenges and transmission potential of PHI.
- To emphasize the importance of early detection and treatment in managing PHI.
- To provide guidance on appropriate screening methods for PHI.
Summary:
- PHI accounts for approximately 50% of HIV transmissions, underscoring its public health significance.
- Symptoms of PHI, such as fever and rash, are often non-specific, complicating clinical diagnosis.
- 4th generation Combo tests are recommended for PHI screening due to their early detection capabilities, while HIV-specific PCR is discouraged for routine screening.
- Early antiretroviral therapy (ART) is recommended for individuals diagnosed with PHI.
Impact:
- Improved diagnostic strategies for PHI can reduce onward transmission.
- Timely initiation of ART in PHI can improve patient outcomes.
- Routine screening of at-risk populations can enhance early detection and intervention efforts.
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