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Updated: Apr 26, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
[Allergic contact dermatitis caused by temporary black henna tattoos in two siblings]
Kasper F Hjuler1, Aksel Otkjær
1Dermatologisk Afdeling, Aarhus Universitetshospital, P.P. Ørums Gade 11, 8000 Aarhus C. khp@ki.au.dk.
Abstract:
Para-phenylenediamine (PPD) in black henna tattoo mixes is widely recognised as a cause of type-IV allergic contact dermatitis. Legislation in Western countries prohibits the use of PPD on the skin and limits the use in hairdye. In this report, we present a case of two brothers aged five and eight years with classical sensitization and illustrative contact dermatitis after repeatedly exposure to black henna. The hyper-sensitivity reaction to PPD was confirmed in later patch testing. The case serves as a reminder on the potential consequences of a seemingly harmless skin drawing.
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