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Normocalcemic hyperparathyroidism and insulin resistance
Sule Temizkan1, Omer Kocak2, Kadriye Aydin1
1Department of Endocrinology and Metabolic Diseases, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.
Summary
Insulin resistance (IR) is not more common in patients with normocalcemic primary hyperparathyroidism (NCPHP). Parathyroid hormone (PTH) levels did not correlate with glucose metabolism markers in this study population.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Calcium Homeostasis
Background:
- Normocalcemic primary hyperparathyroidism (NCPHP) is a subtype of hyperparathyroidism where calcium levels are normal.
- The relationship between NCPHP and metabolic disturbances like insulin resistance (IR) remains unclear.
- Understanding this association is crucial for comprehensive patient management.
Purpose of the Study:
- To investigate the prevalence of insulin resistance (IR) in patients diagnosed with normocalcemic primary hyperparathyroidism (NCPHP).
- To explore potential correlations between parathyroid hormone (PTH) levels and markers of glucose metabolism in NCPHP patients.
Main Methods:
- A case-control study involving 25 NCPHP patients and 25 matched controls.
- NCPHP diagnosis based on normal serum calcium and elevated PTH levels.
- Insulin resistance assessed using oral glucose tolerance test (OGTT), HOMA-IR, and ISogtt.
Main Results:
- No significant difference in IR frequency between NCPHP patients and controls.
- Trends suggested higher HOMA-IR and lower ISogtt in NCPHP, but these were not statistically significant.
- No significant correlation was found between PTH levels and glucose metabolism markers (HOMA-IR, ISogtt, HbA1c, BMI).
Conclusions:
- Insulin resistance is not more prevalent in individuals with normocalcemic primary hyperparathyroidism.
- Parathyroid hormone levels do not appear to be associated with insulin sensitivity or resistance in this cohort.
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