Related Experiment Video
Updated: Apr 26, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive
Adrienne Dow1, Ruth Virginia Russell2, Vivien Bonert2
1Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California.
Objective:
Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.
Methods:
This is a case report.
Results:
Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum.
Conclusion:
This case broadens the clinical spectrum of lymphocytic hypophysitis.
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