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Cohort profile: The Cork BASELINE Birth Cohort Study: Babies after SCOPE: Evaluating the Longitudinal Impact on

Sinéad M O'Donovan1, Deirdre M Murray2, Jonathan O'B Hourihane3

  • 1Vitamin D Research Group, School of Food and Nutritional Science.

International Journal of Epidemiology
|August 9, 2014
PubMed

Insights

The Cork BASELINE Birth Cohort Study examined how intrauterine growth restriction and early nutrition impact infant metabolic health and neurodevelopment. It also assessed food allergy incidence and early feeding practices

Area of Science:

  • Pediatric Health
  • Nutritional Science
  • Developmental Pediatrics

Background:

  • The Cork BASELINE Birth Cohort Study (Babies After Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints) is a key resource for understanding early life influences on health.
  • It builds upon the SCOPE Ireland pregnancy cohort, incorporating additional infant recruitment for a comprehensive sample.

Purpose of the Study:

  • Investigate the effects of intrauterine growth restriction and early nutrition on metabolic health and neurodevelopment.
  • Ascertain the incidence and determinants of food allergy and eczema in early childhood.
  • Describe early infant feeding, supplementation, and nutritional status, and their impact on growth and health outcomes.

Main Methods:

  • Recruited 2137 infants between 2008-2011, with assessments at multiple time points from birth to 5 years (ongoing).
  • Collected biological samples (blood, DNA) and detailed body composition data.
  • Utilized trans-epidermal water loss measurements, dietary assessments, and validated developmental assessments.

Main Results:

  • Data collection ongoing, with initial assessments completed up to 24 months and 5-year assessments in progress.
  • Biobanking of samples and comprehensive data on growth, nutrition, and development established.
  • Longitudinal data on infant health outcomes are being systematically gathered.

Conclusions:

  • The BASELINE study provides a robust dataset for analyzing the long-term effects of early life factors on child health.
  • Findings will contribute to evidence-based recommendations for infant nutrition and care.
  • Further research is ongoing to elucidate the complex interplay between early exposures and later health outcomes.
Abstract

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