[Corneal crystalline deposits in multiple myeloma]

Two cases of multiple myeloma with corneal opacity were reported. Their chief complaint was blurred vision, and general check-up performed prior to cataract operation revealed that one case had multiple myeloma of IgG-kappa and another, of IgG-lambda type. Two corneal buttons obtained at the time of lamellar keratoplasty operations in the IgG-kappa case were studied immunohistopathologically as well as electron microscopically. Corneal opacity observed with a slit lamp was localized at the anterior stroma of both corneas. Immunohistological studies revealed that the deposit was IgG-kappa chain. Transmission electron microscopy disclosed electron-dense extracellular deposits that exhibited a honeycomb appearance and parallel linear structures with a periodicity of 12nm.