Candida biofilm formation on voice prostheses

Area of Science:

• Biomedical Engineering
• Microbiology
• Otolaryngology

Background:

• Total laryngectomy for laryngopharyngeal malignancy significantly impairs laryngeal functions.
• Voice prostheses are crucial for voice rehabilitation post-laryngectomy.
• Silicone voice prostheses are prone to microbial colonization and biofilm formation, leading to device failure.

Purpose of the Study:

• To review factors influencing biofilm formation on voice prostheses.
• To discuss current strategies for preventing microbial colonization and extending prosthesis lifespan.

Main Methods:

• Literature review of factors affecting biofilm formation on voice prostheses.
• Analysis of current strategies to interfere with microbial colonization.

Main Results:

• Candida albicans is a primary colonizer of silicone voice prostheses.
• Biofilm formation compromises voice prosthesis function, potentially causing aspiration pneumonia.
• Current strategies aim to prolong prosthesis life by managing microbial colonization.

Conclusions:

• Biofilm formation on voice prostheses is a significant clinical challenge.
• Further research is needed to fully understand biofilm mechanisms and develop effective prevention strategies.
• Controlling biofilm is essential for device longevity and patient health.