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Effects of surgery on microvascular function in venous insufficiency
Yusuf Sevim1, Zahide Unal2, Cuneyt Koksoy2
1Ankara Penal Institution Campus State Hospital, Department of General Surgery, Ankara, Turkey.
Annals of Vascular Surgery
|August 10, 2014
Summary
Great saphenous vein insufficiency negatively impacts microvascular function. Surgical stripping improved microvascular vasoreactivity and reduced symptoms, indicating partial recovery of vascular health.
Area of Science:
- Vascular Surgery
- Microcirculation Research
- Phlebology
Background:
- Great saphenous vein insufficiency is common, affecting venous function.
- Microvascular dysfunction is a potential consequence of venous insufficiency.
- The impact of surgical intervention on microvascular function requires further investigation.
Purpose of the Study:
- To evaluate the effect of venous stripping on microvascular function in patients with great saphenous vein insufficiency.
- To compare microvascular vasoreactivity between healthy individuals and patients with varicose veins.
- To assess changes in microvascular function post-surgery.
Main Methods:
- Prospective evaluation of two groups: healthy controls (15) and patients with varicose veins (20).
- Assessment of microvascular vasoreactivity using iontophoretic laser Doppler imager.
- Venous stripping surgery performed on patients, with repeat evaluations 6 weeks postoperatively.
Main Results:
- Varicose vein patients showed reduced responses to nitroprusside (SNP) and acetylcholine (ACh) compared to controls.
- Post-surgery, significant improvements in microvascular flow and dilatation were observed in response to SNP and ACh.
- Surgical treatment led to significant relief of pain and edema.
Conclusions:
- Great saphenous vein insufficiency impairs endothelium-dependent vasodilation in the perimalleolar area.
- Venous stripping surgery can lead to partial recovery of microvascular function.
- Surgical intervention offers symptomatic relief and improves vascular health.
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