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Updated: Apr 26, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
Who should receive biologic therapy for IBD?: The rationale for the application of a personalized approach
Jennifer Jones1, Juan Nicolás Peña-Sánchez2
1Department of Medicine, University of Saskatchewan, 108 Hospital Drive, Saskatoon, Saskatchewan S7N0W8, Canada.
Abstract:
The therapeutic approach in inflammatory bowel disease has evolved to target end-organ inflammation to heal intestinal mucosa and avoid structural damage. Objective therapeutic monitoring is required to achieve this goal. Earlier intervention with biologic therapy has been shown, indirectly, to be associated with higher clinical response and remission rates. A personalized approach to risk stratification with consideration of key clinical factors and inflammatory biomarker concentrations is recommended when deciding whether or not to start a patient on biologic therapy.
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