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Updated: Apr 26, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Fluidized bed layer-by-layer microcapsule formation.

Joseph J Richardson¹, Darwin Teng, Mattias Björnmalm

¹Department of Chemical and Biomolecular Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.

Langmuir : the ACS Journal of Surfaces and Colloids

|August 13, 2014

Summary

This summary is machine-generated.

This study introduces a rapid, scalable fluidized bed method for creating polymer microcapsules, achieving high yields. This technique significantly speeds up the production of artificial cells and bioreactors compared to traditional methods.

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Last Updated: Apr 26, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

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Published on: October 13, 2021

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High Throughput Single-cell and Multiple-cell Micro-encapsulation

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

Area of Science:

Biomaterials Engineering
Polymer Science
Cellular Engineering

Background:

Polymer microcapsules serve as valuable bioreactors and artificial cells.
Current preparation methods are often slow, inefficient, or require specialized equipment.

Purpose of the Study:

To develop a rapid, scalable, and efficient method for preparing polymer microcapsules.
To investigate parameters influencing the formation of robust microcapsules using a fluidized bed.

Main Methods:

Utilized a fluidized bed for layer-by-layer (LbL) assembly of polymers.
Investigated effects of polymer concentration, molecular weight, and solution volume.
Validated fluidization for particles >5 μm, comparable to mammalian cells.

Main Results:

Achieved rapid (∼30 min/batch) and scalable (up to 500 mg) microcapsule production with 98% yield.
Identified polymer molecular weight and concentration as key factors for robust capsule formation.
Resultant microcapsules exhibited a bilayer thickness of ∼5.5 nm, consistent with conventional methods.

Conclusions:

The fluidized bed LbL technique offers a significantly faster (∼8x) alternative for microcapsule production.
This method is suitable for scale-up and mass production of polymer microcapsules.
Enables efficient generation of cell-like microcapsules for various applications.