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Updated: Apr 26, 2026
Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
Published on: April 16, 2019
Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability
Monica Terracciano1, Ilaria Rea2, Luca De Stefano2
1Institute for Microelectronics and Microsystems, National Council of Research, Naples 80131, Italy ; Department of Pharmacy, University of Naples Federico II, Naples 80138, Italy.
Abstract:
Rapid screening tests in medical diagnostic and environmental analysis are often based on oligonucleotide biochips. In this paper, we studied the stability of functionalized mesoporous silicon supports in the solid-phase synthesis of oligonucleotides, exploiting several chemical procedures. A 19-mer mixed sequence has been successfully synthesized on aminosilane-modified porous silicon photonic structures. The process and the materials have been characterized by optical reflectivity, atomic force microscopy and high-performance liquid chromatography.
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