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Recurrent IVF failure and hereditary thrombophilia
Leila Safdarian1, Zahra Najmi2, Ashraf Aleyasin1
1Department of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iranian Journal of Reproductive Medicine
|August 13, 2014
Summary
Hereditary thrombophilia is more common in women experiencing recurrent in-vitro fertilization (IVF) failures. Specific thrombophilias, including Factor V Leiden and MTHFR mutations, increase the risk of IVF failure.
Area of Science:
- Reproductive Medicine
- Genetics
- Hematology
Background:
- Recurrent implantation failure is a major cause of in-vitro fertilization (IVF) cycle failure.
- Hereditary thrombophilia is a known risk factor for placental dysfunction and may contribute to recurrent IVF failures.
Purpose of the Study:
- To investigate the prevalence of hereditary thrombophilia in women with recurrent IVF failures.
- To determine if specific inherited thrombophilias are associated with recurrent IVF failure.
Main Methods:
- A case-control study was conducted with 96 women experiencing recurrent IVF failure (cases) and 95 fertile women (controls).
- Participants were tested for inherited thrombophilias: Factor V Leiden, methylenetetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocysteine levels, Protein S and C deficiency, antithrombin III (AT-III) deficiency, and plasminogen activator inhibitor-1 (PAI-1) mutation.
Main Results:
- Women with recurrent IVF failure had a significantly higher prevalence of at least one thrombophilia (OR=3.15, p=0.00).
- Factor V Leiden mutation (OR=3.06, p=0.01) and homozygous MTHFR mutation (OR=12.33, p=0.05) were identified as significant risk factors for recurrent IVF failure.
- No significant differences were found for other tested inherited thrombophilias.
Conclusions:
- Inherited thrombophilia is more prevalent in women with recurrent IVF failure compared to fertile controls.
- The presence of any thrombophilia, Factor V Leiden mutation, and homozygous MTHFR mutation are confirmed risk factors for recurrent IVF failure.
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