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Updated: Apr 25, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Childhood granulomatous periorificial dermatitis]
1Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland, gunnar.wagner@klinikum-bremerhaven.de.
Case Report:
A 14-year-old patient of African ancestry presented with multiple papules in the perioral, perinasal and periocular areas. Histopathology showed sarcoidal granulomas.
Diagnosis:
After exclusion of systemic sarcoidosis, the diagnosis of childhood granulomatous periorificial dermatitis was made.
Therapy:
Topical treatment with erythromycin resulted in complete regression.
Conclusion:
Childhood granulomatous periorificial dermatitis is mainly observed in dark-skinned children of African, Caribbean, or Asian origin. The nosological position of the dermatosis is controversial. Originally classified as sarcoidosis, childhood granulomatous periorificial dermatitis is now generally regarded as a special form of perioral dermatitis.
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