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Combining collagen and bioactive glasses for bone tissue engineering: a review.
Bapi Sarker1, Jasmin Hum, Showan N Nazhat
1Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058, Erlangen, Germany.
Advanced Healthcare Materials
|August 14, 2014
Summary
Collagen-bioactive glass composites enhance bone tissue engineering by improving mechanical properties and promoting cell growth. This review covers fabrication, in vitro, and in vivo studies of these promising biomaterials.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Biomedical Engineering
Background:
- Collagen (COL) is a biocompatible protein with high water affinity, ideal for biomedical uses.
- COL's limited mechanical properties restrict its applications, particularly in bone tissue engineering.
- Combining COL with bioactive inorganic materials, like bioactive glass (BG), can overcome these limitations.
Purpose of the Study:
- To review collagen-bioactive glass (COL-BG) composites for bone tissue engineering.
- To analyze fabrication methods, in vitro cell studies, and in vivo performance.
- To identify future research directions for COL-BG systems.
Main Methods:
- Literature review of COL-BG composite fabrication and characterization over the last 15 years.
- Analysis of in vitro cell studies assessing osteogenic, odontogenic, and angiogenic potential.
- Evaluation of in vivo studies examining bony integration and connective tissue formation.
Main Results:
- BG fillers significantly improve the compressive strength and stiffness of COL-based structures.
- In vitro studies confirm COL-BG composites stimulate osteogenesis, odontogenesis, and angiogenesis.
- In vivo implantation demonstrates successful bony integration and vascularization.
Conclusions:
- COL-BG composites show significant potential for bone tissue engineering applications.
- Further research is needed to address current challenges and knowledge gaps in COL-BG systems.
- Optimizing COL-BG composite design can lead to advanced regenerative medicine solutions.
