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[Effect of peritol on gastric secretory function].
Vrachebnoe Delo
|August 1, 1989
Summary
Peritol significantly inhibits gastric secretion in dogs stimulated by insulin and carbacholine, with a weaker effect on pentagastrin-stimulated secretion. It also inhibits pepsin during histamine secretion, suggesting clinical gastroenterology applications.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastric acid secretion is a complex physiological process.
- Understanding the effects of pharmacological agents on gastric function is crucial for treating acid-related disorders.
Purpose of the Study:
- To investigate the inhibitory effects of Peritol on gastric secretory function.
- To compare the efficacy of Peritol against different secretory stimuli.
Main Methods:
- Gastric fistulas were surgically created in dogs.
- Gastric secretion was stimulated using insulin, carbacholine, pentagastrin, and histamine.
- The effects of Peritol on gastric juice volume, acidity, and pepsin content were measured.
Main Results:
- Peritol markedly inhibited gastric secretion stimulated by insulin and carbacholine.
- The inhibitory effect of Peritol on pentagastrin-stimulated gastric secretion was less pronounced.
- Peritol inhibited pepsin secretion in response to histamine stimulation.
Conclusions:
- Peritol demonstrates significant inhibitory effects on canine gastric secretion.
- The drug's efficacy varies depending on the secretory stimulus.
- These findings suggest potential clinical applications for Peritol in gastroenterology.