Related Experiment Video
Updated: Apr 25, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
Global sodium consumption and death from cardiovascular causes
Dariush Mozaffarian1, Saman Fahimi, Gitanjali M Singh
1From the Friedman School of Nutrition Science and Policy, Tufts University (D.M.), the Departments of Epidemiology (D.M., S.F., G.M.S., R.M., S.K., G.D.), Nutrition (D.M.), and Global Health and Population (G.D.), Harvard School of Public Health, and the Division of Cardiovascular Medicine and Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (D.M.) - all in Boston; the Department of Public Health and Primary Care, Cambridge Institute of Public Health, Cambridge (S.F., J.P.), and the MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London (M.E.) - both in the United Kingdom; and the Institute for Health Metrics and Evaluation, University of Washington, Seattle (R.E.E., S.L.).
High sodium intake significantly contributes to cardiovascular disease deaths globally. Reducing sodium consumption could prevent millions of premature deaths each year.
Area of Science:
- Public Health
- Cardiovascular Epidemiology
- Nutritional Science
Background:
- High sodium intake is a known risk factor for elevated blood pressure and cardiovascular disease.
- The precise global impact of sodium consumption on cardiovascular mortality remains uncertain.
Purpose of the Study:
- To quantify global sodium consumption patterns across different demographics and countries.
- To estimate the cardiovascular mortality attributable to excessive sodium intake worldwide.
Main Methods:
- Utilized survey data on sodium intake (urinary excretion and diet) from 66 countries.
- Integrated meta-analyses of sodium's effect on blood pressure and blood pressure's effect on mortality.
- Employed comparative risk assessment to estimate cardiovascular effects versus a 2.0 g/day reference intake.
Main Results:
- Global average sodium consumption was 3.95 g/day in 2010, with significant regional variations.
- An estimated 1.65 million annual cardiovascular deaths were linked to sodium intake exceeding the reference level.
- The majority of these deaths occurred in men, low- and middle-income countries, and were premature.
Conclusions:
- Sodium consumption above 2.0 g/day was associated with 1.65 million cardiovascular deaths in 2010.
- Findings highlight the substantial global burden of cardiovascular disease attributable to high sodium intake.
- Public health strategies targeting sodium reduction are crucial for mitigating cardiovascular mortality.
Related Concept Videos
Disorder of Water Balance
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
Heart Failure VI: Adjunct Therapies
Antiarrhythmic Drugs: Class I Agents as Sodium Channel Blockers
Class 1A Antiarrhythmic Drugs: These drugs work by moderately blocking sodium channels,...
Assessment of the Cardiovascular System I: Subjective Data
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Hypertension and Regulation of Blood Pressure