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Arterial pressure and flow wave analysis using time-domain 1-D hemodynamics
Marie Willemet1, Jordi Alastruey
1Division of Imaging Sciences and Biomedical Engineering, St. Thomas' Hospital, King's College London, London, UK, marie.willemet@kcl.ac.uk.
Annals of Biomedical Engineering
|August 21, 2014
Summary
This study reviews arterial waveform analysis methods, combining techniques like wave intensity analysis to understand blood flow dynamics and identify contributions from various arterial segments and conditions.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
- Computational Fluid Dynamics
Background:
- Arterial blood pressure and flow waveforms reflect complex physiological mechanisms.
- Existing time-domain analysis methods include wave intensity analysis and waveform separations.
- Understanding these patterns is crucial for diagnosing and treating cardiovascular diseases.
Purpose of the Study:
- To review and assess existing time-domain methods for analyzing arterial waveform mechanisms.
- To demonstrate how to combine these methods for a comprehensive analysis.
- To quantify contributions to numerically generated waveforms from specific arterial regions and conditions.
Main Methods:
- Review of established time-domain analysis techniques for arterial hemodynamics.
- Waveform separation into forward/backward, peripheral/conduit, and reservoir/excess components.
- Numerical modeling incorporating factors like arterial stiffening, stenosis, stents, and aneurysms.
Main Results:
- Wave intensity analysis and waveform separations provide distinct physical insights.
- Combining methods allows quantification of waveform contributions from different sources.
- Numerical examples illustrate the impact of arterial pathologies on waveform patterns.
Conclusions:
- Integrated analysis of arterial waveforms offers a powerful approach to understanding cardiovascular mechanics.
- This framework can elucidate the impact of localized and generalized arterial changes.
- The combined methods enhance the interpretation of complex hemodynamic phenomena.
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