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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Natural compounds in epigenetics: a current view.

Marco Miceli1, Paola Bontempo2, Angela Nebbioso2

  • 1Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Universita' di Napoli, Via L. De Crecchio 7, 80138 Napoli, Italy; Istituto di Genetica e Biofisica, Adriano Buzzati-Traverso, IGB, Via P. Castellino 111, 80131 Napoli, Italy.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|August 21, 2014
PubMed
Summary
This summary is machine-generated.

Natural compounds offer promising anticancer agents by influencing chromatin remodeling. This review highlights their potential in personalized medicine, addressing challenges in predicting patient response to cancer therapies.

Keywords:
CancerEpigeneticsNatural compounds

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Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Predicting patient response to cancer therapy remains a significant challenge.
  • Synthetic drugs have often failed due to a lack of understanding of molecular pathways.
  • Personalized medicine demands novel therapeutic tools.

Purpose of the Study:

  • To review current knowledge on natural compounds with anticancer properties.
  • To emphasize natural compounds that exhibit chromatin remodeling effects.
  • To explore the potential of these compounds in personalized cancer treatment.

Main Methods:

  • Literature review of scientific databases.
  • Analysis of studies on natural products and their mechanisms of action.
  • Focus on compounds with dual chromatin remodeling and anticancer effects.

Main Results:

  • The biodiversity of natural compounds is underexplored but rapidly expanding.
  • Several natural compounds show potential for chromatin remodeling.
  • These compounds may offer new avenues for cancer treatment.

Conclusions:

  • Natural compounds with chromatin remodeling effects represent a promising area for anticancer drug development.
  • Further research into these compounds could advance personalized medicine.
  • Exploring nature's chemical diversity is crucial for future therapeutic strategies.