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Updated: Apr 25, 2026
Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease
Published on: April 19, 2021
Promising two-photon probes for in vivo detection of β amyloid deposits
N Arul Murugan1, Robert Zaleśny, Jacob Kongsted
1Division of Theoretical Chemistry and Biology, School of Biotechnology, Royal Institute of Technology, SE-10691 Stockholm, Sweden. murugan@theochem.kth.se.
Abstract:
Based on electronic structure calculations we propose that particular small-sized organic molecules - donor-acceptor substituted phenyl polymethines - can be used as two-photon diagnostic probes for non-invasive imaging of amyloid oligomers and fibrils, which are often referred to as the "early signatures" of Alzheimer's disease.
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