In vitro effect of menfegol on Neisseria gonorrhoeae

Bacteriostatic and bactericidal effect of Menfegol, which has been used as a spermicide, on Neisseria gonorrhoeae was investigated in vitro. The distribution of the MICs of N. gonorrhoeae to Menfegol consisted of 2 groups. Resistant strains showed the MICs of more than 3200 micrograms/ml while the MICs of sensitive strains were less than or equal to 200 micrograms/ml. When the resistant strains were suspended in several concentrations of Menfegol and were incubated at 35 degrees C, no concentrations inactivated gonococci completely. However, the number of organisms was remarkably decreased within 30 minutes.