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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
Published on: June 28, 2011
Improved and optimized one-pot method for N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) synthesis using
Kang-Po Li1, Ming-Kuan Hu2, Clifton Kwang-Fu Shen3
1Department of Nuclear Medicine/PET Center, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-kung Rd., Neihu District, Taipei City 114, Taiwan, ROC; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, 23-120 Center for Health Science, Los Angeles, CA 90095, USA; Crump Institute for Molecular Imaging, 570 Westwood Plaza, Los Angeles, CA 90095, USA; California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA 90095, USA.
Abstract:
N-Succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [(18)F]SFB with high efficacy. Herein, we reveal an improved and optimized approach based on this former model for producing [(18)F]SFB. With optimized approaches, the entire protocol can be completed within 25min, and [(18)F]SFB is generated in satisfactory quality for direct use without further purification via high-performance liquid chromatography.
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